2 edition of Investigations of optically active polymeric chiral stationary phases found in the catalog.
Investigations of optically active polymeric chiral stationary phases
Elizabeth Jane Kelly
Thesis (Ph.D.) - University of Warwick, 1997.
|Statement||Elizabeth Jane Kelly.|
|The Physical Object|
|Number of Pages||180|
Comparison of the factors that contribute to retention on immobilized polysaccharide-based chiral stationary phases and macrocyclic glycopeptide chiral stationary phases with the Abraham model. Mitchell, Clifford R., Benz, Nancy J., Zhang, Shuhong, Journal of Chromatography, B: Analytical Technologies in the Biomedical and Life Sciences ( The optical resolution of ten racemates by supercritical fluid chromatography (SFC) was investigated using phenylcarbamates of cellulose and amylose and 4-methylbenzoate of cellulose as chiral stationary phases (CSPs) and carbon dioxide–alcohol as a mobile phase.
This book presents a systematic study of the synthesis of optically active polymers, discussing in detail the syntheses of three different types of optically active polymers from helical polymers, dendronized polymers and other types of polymeric compounds. It also explains the syntheses of. 1. J Chromatogr A. Jan 12;() Optically active synthetic polymers as chiral stationary phases in HPLC. Nakano T(1). Author information: (1)Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), Ikoma, Japan. [email protected] Synthetic, optically active polymers used as CSP are reviewed.
Optically active polyesters were synthesized from chiral (2R,4R)-pentane-2,4-diol or its analogues and various aromatic diacid chlorides in refluxing 1,2 . Optical activity is a physical spectral property of chiral matter caused by asymmetrical configurations, conformations and structures which have no plane and no center of symmetry and consequently have two mirror image enantiomeric forms of inverse optical rotation. The racemic mixture of chiral enantiomers is optically inactive.
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Cyclic olefins afford optically active polymers by asymmetric synthesis polymerization. The first example was the polymerization of benzofuran () with AlEtCl 2 or AlCl 3 in the presence of optically active cocatalysts such as β-phenylalanine and CSA; the polymer is considered to possess the chiral erythro- or threodiisotactic structure (a or b).
,– Binary. This thesis describes the application of optically active helical polymers to chiral stationary phases for high performance liquid chromatography. The use of porous graphitic carbon as a support for these phases is examined and its implication for the nature of the separation.
In the first case 3,5-dimethylphenyl carbamate (CDMPC) was studied. This thesis describes the application of optically active helical polymers to chiral stationary phases for high performance liquid chromatography.
The use of porous graphitic carbon as a support for these phases is examined and its implication for the nature of the separation. In the first case 3,5-dimethylphenyl carbamate (CDMPC) was : Elizabeth Jane Kelly.
Enter the password to open this PDF file: Cancel OK. File name:. In the past two decades, various optically active polymers have been utilized as the chiral stationary phases (CSPs) for high-performance liquid.
Several optically active polymers, such as polymethacrylates, polyacrylamides, polyacetylenes, and polysaccharide derivatives, exhibit high chiral recognition when used as a chiral stationary phase for high‐performance liquid chromatography (HPLC).
A pair of optically active triptycene derivatives ((R,R)- and (S,S)-8) with a distorted cyclic structure were synthesized via an intramolecular etherification and evaluated as a novel chiral selector for high-performance liquid (R,R)- and (S,S)based chiral stationary phases (CSPs) were found to be particularly effective in the resolution of axially chiral.
The asymmetric polymerization is carried out using a complex of an organolithium with a chiral ligand or using a chiral organolithium 9–11).The helix-sense-selection is governed by the chirality of the ligand or the initiator (Fig.
1 A and B).Several chiral ligands including Sp, 6-benzylsparteine (BzSp), 2,3-dimethoxy-1,4-bis(dimethylamino)butane (DDB), and (+)-1.
First published on 5th June A pair of optically active triptycene derivatives ((R, R)- and (S, S)-8) with a distorted cyclic structure were synthesized via an intramolecular etherification and evaluated as a novel chiral selector for high-performance liquid (R, R)- and (S, S)based chiral stationary phases (CSPs) were found to be particularly effective in the.
Synthetic polymers with optically active amide, amino acid, and crown ether groups, natural products such as starch and cellulose, and also microcrystalline triacetylcellulose are suitable for this purpose.
Racemates can also be resolved by gas chromatography on optically active stationary phases. A synthetic polymeric chiral stationary phase for liquid chromatography based on N, N′-[(1R,2R)-1,2-diphenyl-1,2-ethanediyl]bispropenamide monomer was prepared via a simple solution initiated.
Synthesis of Optically Active Poly (diphenylacetylene)s Using Polymer Reactions and an Evaluation of Their Chiral Recognition Abilities as Chiral Stationary Phases for HPLC. Molecules21 (11), DOI: /molecules Katsuhiro Maeda, Miyuki Maruta, Kouhei Shimomura, Tomoyuki Ikai, Shigeyoshi Kanoh.
Three-State Switchable Chiral Stationary Phase Based on Helicity Control of an Optically Active Poly(phenylacetylene) Derivative by Using Metal Cations in the Solid State Daisuke Hirose WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, KanazawaJapan.
To separate enantiomers, we usually have to receive the aid of chiral, optically active compounds or materials. In usual chromatographic resolutions by gas or liquid phase, the chiral materials have been called as the chiral stationary phases (CSPs). Synthesis of Optically Active Poly (diphenylacetylene)s Using Polymer Reactions and an Evaluation of Their Chiral Recognition Abilities as Chiral Stationary Phases for HPLC by Katsuhiro Maeda *, Miyuki Maruta, Yuki Sakai, Tomoyuki Ikai and Shigeyoshi Kanoh.
rials [31–33]. Chiral recognition of optically active polymers has been utilized in various forms of cat-alytic and separation chemistry. For example, one of the generally function of chiral polymers is the use as chiral stationary phase in high-performance liquid chromatography (HPLC) for the separation of racemic mixtures [2, 34–38].
A paper reviewing the production of optically active pharmaceutical compounds. Molecules that are non-super imposable mirror images of one another are termed as chiral.
These are a pair of enantiomers and are diasymmetric as well as optically active. Since they promote optical rotation, these enantiomers are also known as optical isomers.
optically active polymers . Chiral polymers have found widespread applications, including the chiral liquid crystals, nonlinear optical devices, optical switches, biomedical devices [3–7], as well as asymmetric catalysis applications [2,8,9] and the chiral stationary phases in high-performance liquid chromatography (HPLC) [10–12].
Dossou KSS, Chiap P, Chankvetadze B, Servais AC, Fillet M, Crommen J () Optimization of chiral pharmaceuticals enantioseparation using a coated stationary phase with cellulose tris(4-chloromethyl-phenylcarbamate) as chiral selector and non-aqueous polar mobile phase.
So the fact that this is (S)-Carvone has nothing to do with the fact that this is positive. R and S are used to assign a configuration to a chiral center. And the negative and positive of specific rotations, have to be determined experimentally.
So we've seen that chiral compounds are optically active, but achiral compounds are not. The optically active ligands like amino acids are bound covalently to a solid support, thereby forming a chiral stationary phase.
Various amino acid derivatives like N -(3,5-dinitrobenzoyl) phenyl glycines are also used.(Pirkle and Pochapsky,).
Optically pure compounds are also used in chiral synthesis. InSharpless, Knowles and Noyori received the Nobel Prize for research on the oxidation and hydrogenation reactions using optically active compounds which have found application in the production of many antibiotics and anti-inflammatory and cardiac drugs (Kaniewska ).and used as chiral stationary phases for high-performance liquid chromatography,12 there were relatively few reports on the relationship of the stereoregularity with both chiropti-cal properties and chiral discrimination with respect to these optically active .